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Stavudine (Two'-Trio'-didehydro-Two'-Trio'-dideoxythymidine, d4T, trade name Zerit®) occurs as thymidine analogue active against HIV. These are phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits a reverse transcriptase by competing with natural substrate, deoxythymidine triphosphate. It besides stimulates termination of DNA synthesis by incorporating into it.
A unwritten absorption rate of stavudine is complete Eighty %. Just about half of stavudine is actively secreted unchanged into a weewee & a more half is eliminated across endogenous pathways. Coincident have of AZT is not recommended, for AZT could inhibit a intracellular phosphorylation of stavudine. More anti-HIV doses don't possess this property. A independent severe side burden is peripheral neuropathy, which can be corrected by reducing dose. Stavudine has been shown inside laboratory end line text to exist as genotoxic, but by having clinical drugs its carcinogenic effects come non-wanting.
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Stavudine
a.k.a. d4T, Zerit.
Zerit
Information about Zerit, HIV, side effects, coping tips, glossary terms, and resource links.
Stavudine
(d4T, Zerit)
DrugDigest: Stavudine ( Zerit )
Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.
Zerit
Full prescribing information from RxList.
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